Relationship between hyperuricemia and neutrophil-to-lymphocyte ratio in type 2 diabetes mellitus

Aims/Introduction: To research the relationship between Serum uric acid (SUA) levels and the Neutrophilto-lymphocyte Ratio (NLR) of Type 2 Diabetes Mellitus patients. Materials and methods: 290 newly diagnosed Type 2 Diabetes Mellitus patients are selected in accordance with the WHO diagnostic criteria: Male subjects with SUA levels ≥416 μmol/L (60 mg/L), and female subjects with SUA levels ≥357 μmol/L (70 mg/L), a total of 234 subjects, are sorted into the high SUA (HUA) group, and the rest, a total of 56 subjects, into the normal SUA (NUA) group. 130 subjects were selected as a control group. One-Way analysis of variance (etc) was applied to the data of the three groups; Pearson correlation analysis was used to calculate the correlation of SUA levels, NLR and IR; risk factors influencing SUA levels were analyzed with Logistic regression analysis; ROC curve analysis was used to determine the diagnostic value of NLR to HUA, and the optimal threshold value of NLR. Result: (1) The NLR and IR of the HUA group was significantly higher than those of the NUA group (2.54±0.64 vs. 2.06±0.62, P<0.001; 3.70±1.83 vs. 2.71±1.54, P<0.001); (2) In the HUA group, UA was positively correlated with NLR and IR (respectively r=0.512, P<0.001; r=0.357, P<0.001). (3) NLR (P=0.011, EXP(B)=5.237, 95% CI=1.465-18.719) was a risk factor of Hyperuricemia. Conclusion: Our results suggest that NLR may be an independent risk factor of Hyperuricemia.